In Wireless Sensor Network (WSN) clustering routing algorithm, sensors energy consumption imbalance will result in "energy hole" phenomenon, and it will affect the network lifetime. For this problem, an energy-balanced unequal clustering routing protocol based on game theory named GBUC was put forward. In clustering stage, WSNs were divided into clusters of different sizes, the cluster radius was determined by the distance from cluster head to sink node and the residual energy. By adjusting the cluster head in the energy consumption of communication within the cluster and forwarding data to achieve energy balance. In inter-cluster communication phase, a game model was established by using the residual energy efficiency and link reliability as the benefit functions, using its Nash equilibrium solution to get joint energy balancing, optimal transmission path of link reliability, thereby improving network performance. The simulation results show that, compared with Energy-Efficient Uneven Clustering (EEUC) algorithm and Unequal Clustering Energy-Economical Routing (UCEER) algorithm, the GBUC algorithm has significantly improved the performance in balancing node energy consumption and prolonging the network lifetime.